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6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE
Descriptors Found:
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DeCS
Descriptor
English
:
Phosphofructokinase-1, Muscle Type
Descriptor
Spanish
:
Fosfofructoquinasa-1 Tipo Muscular
Descriptor
Portuguese
:
Fosfofrutoquinase-1 Muscular
Synonyms
English
:
6-Phosphofructokinase, Muscle Type
Phosphofructo-1-kinase Isozyme A
Phosphofructokinase 1, Muscle Type
Tree Number:
D08.811.913.696.620.225.850.500.500
Definition
English
:
An allosteric enzyme that regulates
glycolysis
by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In
humans
,
PHOSPHOFRUCTOKINASE-1
in muscle exists as the homotetramer of M subunits. Defects in this muscle enzyme cause
GLYCOGEN STORAGE DISEASE TYPE VII
, also known as Tarui's
disease.
Entry Combination - descr/qualif
English
:
Phosphofructokinase-1, Muscle Type
/
deficiency
use
Glycogen Storage Disease Type VII
History Note
English
:
2002
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
36114
Unique Identifier:
D025203
Occurrence in VHL
:
Similar:
DeCS